Manifestations:

Newborn and infancy:

– Hypotonia

– Feeding difficulties

   may need NGT feeds

– Failure to thrive

– Developmental delay

 

Early childhood:

– Hyperphagia starts

– Leads to Obesity

– Relatively small hands / feet

– Short stature

 

Older children:

– Obesity

– Learning difficulties

– Behavioural disorder

– Boys: undescended testes,   

   hypogonadism

– Girls: premature adrenarche